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Trends Pharmacol Sci (2012) 33(12):65668.10.1016/j.tips.2012.09.007 65 TewKDTownsendDM

Studies have shown that vitamin D can inhibit TGF--Smad signaling pathway (156, 158160) through the specific process of 1,25(OH) 2 D 3 binding complex with VDR, which directly interacts with SMAD3 to reduce the binding of SMAD3 to DNA, and ultimately inhibit TGF--Smad signal transduction (161, 162)

Abnormal mitochondrial content and energy metabolism, mitochondrial dynamics changes are all associated with mitochondrial dysfunction in fatty liver diseases

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